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NonoverlappingrolesofPD-1andFoxP3inmaintainingimmunetoleranceinanovelautoimmunepancreatitismousemodel
BaihaoZhang.etal.
PNAS,
ForhumansormiceFoxp3+TregcellsconstitutivelyexpressPD-1underdiversecondition,theauthorswanttoknowtheprecisefunctionofPD-1inFoxp3+Tregcells.Thus,theycrossedPD-1KOmicewithFoxp3-GFPcremicewhichcarriedtheIRES-GFPcrereporterKIatthe3’untranslatedregionoftheFoxp3gene.LossofPD-1inFoxp3-GFPcreKI/YandFoxp3-GFPcreKI/KImiceincurreddeathintheirearlyagesandtheyalsofoundthatFoxp3expressionisreducedinFoxp3-GFPcremice